South-South collaboration has proven critical in empowering developing countries to enhance their capacities and find innovative solutions to development challenges. UNDP's Digital Health for Development Hub facilitates knowledge exchange and technology transfer across LMICs, while USAID's digital connectivity efforts in the Pacific, alongside ADB's focus on enhancing national health financing through digital technologies, provide valuable resources to scale up these efforts. However, challenges such as the digital divide, varying levels of technological readiness, and governance capacity persist, especially among least developed countries (LDCs) and small island states. This session aims to explore how South-South collaboration and knowledge exchange can drive the scale-up of digital health innovations across regions, particularly in the Asia-Pacific.